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Dr. Norman Spack at Boston's Children's Hospital has worked with 30 transgender youth and their families to get through the difficult phases of adolescence. One treatment includes a controversial medication that blocks puberty until he or she decides whether or not to transition to the other gender. Dr. Spack talks with guest host Allison Keyes.

1948 The Electronic Sackbut
The history of touch technology begins with touch-sensitive music synthesizers. According to the Canada Science and Technology Museum, Hugh Le Caine's Electronic Sackbut, completed in 1948, is widely considered to be the first musical synthesizer. The Sackbut is played with the right hand on the keyboard and the left hand on control board above the keyboard. The right hand controls volume by applying more or less pressure on the keys, while the left hand controls four different sound texture options.

This week on Fresh Air, we're marking the year's end by revisiting some of the most memorable conversations we've had in 2011. This interview was originally broadcast on May 23, 2011.