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On the campaign trail, GOP presidential candidate Rick Santorum often discusses his opposition to abortion rights and gay marriage. That message served him well in Iowa with its large contingent of evangelical voters. Christian conservatives are also dominant in South Carolina, which votes Saturday. Santorum hopes to repeat his Iowa performance, but he's been struggling to keep pace in polls.

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With those stakes high in South Carolina, the political ads are getting more pointed.

As NPR's Brian Naylor reports, the candidates themselves are taking aim less at each other and more at the White House.

BRIAN NAYLOR, BYLINE: The day before the South Carolina primary, the remaining Republican candidates are making their final TV pitches to voters. Here's part of what the Mitt Romney campaign bills as its closing argument.

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Newt Gingrich's swift rise has been fueled by one thing above all — his forceful performances in the debates. And Thursday night, Gingrich was dominant from the start when he got the first question. It was about an explosive television interview with his ex-wife Marianne.

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As Mara just mentioned, the debate last night opened with a question about a claim made by Gingrich's ex-wife. Well, Marianne Gingrich gave her exclusive interview to ABC's "Nightline," putting the candidate's personal life in the spotlight once again. NPR's Tamara Keith has more.

TAMARA KEITH, BYLINE: The interview was incredibly hyped, in part because Marianne Gingrich has been silent so far on her ex-husband's presidential candidacy. This was her first television interview since their 1999 divorce.